Acute Kidney Injury after Hemorrhagic Shock and its Relation to IL-10 and HSP70

Acute kidney injury after hemorrhagic shock resuscitation in relation to IL-10 and HSP 70 was examined. IL-10 and IL-6 elevated at 2h after hemorrhagic shock and resuscitation at wild type. IL-6 at 2h in KO type showed higher level compared to wild type at 2h. On the contrary, histological section showed that renal tubule was more damaged at wild type at 48h compared to IL-10 knockout type at 48h. HSP 70 was expressed more at renal tubule in KO type at 48h than that of wild type at 48h. From these results, we speculate that 1) IL-10 may aggravate the renal tubule, or 2) IL-6 may work as anti-inflammatory effect or 3) coexisting of IL-6 and IL-10 may produce the kidney injury at renal tubule region, or 4) HSP 70 may ameliorate the acute kidney injury at renal tubular region.